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2024 Update: Dementia Prevention by Aldora Health Inc
Journal Club: by Aldora Health Inc
A colorful circular infographic titled '18 Targets for Dementia Prevention' with a message in the center stating 'Dementia is preventable in 45% of people.' The infographic lists factors such as vision, anxiety, alcohol, blood pressure, blood sugar, cholesterol, depression, exercise, fall prevention, hearing, hobbies, medications, mindset, nutrition, sleep, smoking, social life, and weight. The bottom of the image contains a call to action: 'Learn how to prevent dementia at aldora.ca' with a QR code and the Aldora Health Inc. logo.
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A printable dementia prevention checklist with tips for maintaining health, including wearing hearing aids, sunglasses, staying socially active, exercising, eating a Mediterranean diet, pursuing hobbies, reducing alcohol and smoking, sleeping well, managing health conditions, managing depression and anxiety, preventing falls, stopping sleep pills, and building a growth mindset. The image includes a QR code and a website address for more information.
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The Lancet commission on Dementia Prevention found at least 45% of world-wide cases of dementia could be prevented by managing 14 modifiable risk factors.

An infographic titled "Timing Matters" showing risk factors for dementia categorized by life stages: Early Life (under 18), Mid Life (18-65), and Late Life (over 65). The early life section highlights education and lifelong learning. The midlife section lists hearing loss, high LDL cholesterol, depression, traumatic brain injury, physical inactivity, diabetes, smoking, hypertension, obesity, and excessive alcohol. The late life section emphasizes social isolation, air pollution, and vision loss. The infographic notes there are 14 modifiable risk factors for dementia as of 2024, with some marked as new in 2024.*

  • Livingston et al, Dementia prevention, intervention, and care, The Lancet, 2024.


    To read the article click here

    If you don’t have access through your institution, you can request the PDF directly from the authors for free here

  • Download summary slides here.

    The 14 modifiable risk factors are:

    1. Hearing

    2. Vision

    3. Early life education

    4. High cholesterol

    5. Depression

    6. Traumatic brain injury

    7. Physical inactivity

    8. Diabetes

    9. Smoking

    10. Hypertension

    11. Social isolation

    12. Air pollution

    13. Obesity

    14. Excessive alcohol

    Emerging risk factors (more evidence is still needed but there is a signal for increased risk) include:

    1. Sleep

    2. Diet

    3. Infections and systemic inflammation

    4. Psychiatric disorders including, bipolar disorders, psychotic disorders, anxiety, and PTSD

    5. Menopause

Evidence from RCT's shows cognitive function can be improved in older adults at risk for dementia through multicomponent lifestyle interventions

An illustration of a traffic light with a red light at the top, a yellow light in the middle, and a green light at the bottom. The red light is illuminated, indicating the stop signal.

  • World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia, Alzheimer's & Dementia, 2020

    Link to article click here

  • Effect of Personalized Risk-Reduction Strategies on Cognition and Dementia Risk Profile Among Older Adults: The SMARRT Randomized Clinical Trial, Yaffe et al, JAMA, 2023.

    Link to the abstract here.

    Summary: personalized interventions improved cognition in people aged 70-89 over a 2 year period compared to controls.

The World Health Organization released evidence-based guidelines on lifestyle behaviours and interventions to delay or prevent cognitive decline and dementia.

Graphic illustration of a brain divided into two halves, with the left side in teal and the right side in orange. The image is titled 'Risk Reduction of Cognitive Decline and Dementia,' and includes the WHO guidelines. The World Health Organization logo is at the bottom.

  • World Health Organization, Risk reduction of cognitive decline and dementia, 2019.

    Link to article click here

In Canada, an estimated 51.9% (32.2% to 68.0%) of dementia among men and 52.4% (32.5% to 68.7%) among women could be prevented by addressing 12 modifiable risk factors including sleep.

Title page of a scientific research article discussing potentially modifiable dementia risk factors in Canada, including authors and their affiliations.

  • Potentially Modifiable Dementia Risk Factors in Canada: An Analysis of Canadian Longitudinal Study on Aging with a Multi-Country Comparison, 2024

    Link to article click here

Canadian guidelines in 2020 recommend management of 8 risk factors including nutrition, physical activity, hearing, sleep, cognitive training and stimulation, social engagement and education, frailty, and medications.

Title page of a scientific article titled "CCCDTD5: Reducing the risk of later-life dementia. Evidence informing the Fifth Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD-5)." The authors listed include Kenneth Rockwood, Melissa K. Andrew, Mylène Aubertin-Leheudre, Sylvie Belleville, Louis Bher, Susan K. Bowles, D Scott Kehler, Andrew Lim, Laura Middleton, Natalie Phillips, and Lindsay M.K. Wallace. The top of the page shows received, accepted, and published online dates from August to October 2020, along with a DOI number.

  • Rockwood et al, CCCDTD5: Reducing the risk of later-life dementia, Alzheimer's & Dementia, 2020

    Link to article click here

Dementia prevention strategies are hard to implement in primary care due to time constraints, stigma around dementia, and lack of awareness of the preventability of dementia.

Research article titled "Dementia prevention and the GP's role: a qualitative interview study" with the authors' names listed. The article includes sections on abstract, background, aim, design and setting, method, results, and conclusion, highlighting the role of general practitioners in dementia prevention and the importance of a holistic approach.

  • Dementia prevention and the general practitioner's role, British Journal of General Practice, 2023

    Link to article click here

What we do

We help patients learn how to prevent dementia, largely through lifestyle changes.

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At least 50% of dementia cases are preventable in Canada, but it’s not easy to put this science into action.

Prevention takes guidance, patient education, and system-level changes to make healthy actions easier to do.

This is a tall order for the time-constrained appointments of modern medicine, and yet the brunt of prevention feels like it falls to you.

Aldora is your partner in patient education, filling the space between your diagnosis and direction.

You say “We need to improve your sleep and exercise” . We say “Aldora will show you how”.

Topics that we cover

Exercise
Fall Prevention
Genetics
Hearing
Hobbies
Medications
Menopause

See Content

Mindset
Nutrition
Sleep
Smoking
Social Life
Vision
Weight

Aging
Alcohol
Anxiety
Blood Pressure
Blood Sugar
Cholesterol
Depression

Who is Aldora designed for?

Smiling older woman holding a blue yoga mat and a yellow water bottle, standing outdoors in a park with a blurred green background.

People 50+ or older

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Comfortable using the internet & email

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Interested in learning about
brain health

Our Team

  • Dr. Olivia Geen

    Dr. Olivia Geen

    CEO & Founder
    Adjunct Assistant Professor, University of Toronto

    Read Bio
  • A man with light skin, brown hair, and glasses smiling outdoors with green foliage in the background, wearing a blue blazer and white shirt.

    Dr. Sam Thrall

    Geriatric & Internal Medicine
    Assisstant Professor, McMaster Univeristy

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  • A male doctor with dark hair, wearing a white coat and stethoscope, standing in a hospital corridor.

    Dr. Jason Kerr

    Geriatric & Internal Medicine
    Clinical Lecturer, University of Toronto

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  • A smiling woman with long brown hair wearing blue scrubs and a stethoscope around her neck, in a professional healthcare setting.

    Dr. Laiya Carayannopoulos

    Intensive Care & Internal Medicine
    Adjunct Assistant Professor, McMaster University

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Our promise

Our goal is to make life easier.

If at any time you find Aldora’s work creates challenges for you or your patients, please contact us directly below. Anonymous or identified reports submitted through the following link go directly to our CEO.

We will make it right and change what needs to be changed.

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